Here is a small part about Alex and Izzie!

TVGuide.com: Jackson is not the only Mercy Wester who likes a Seattle Gracer. Reed (Nora Zehetner) and Alex (Justin Chambers) are developing a budding relationship. Are the Mercy Westers just home wreckers?
Williams: We are just a passionate people, the Mercy Westers. We know what we like and we take what we like. That’s probably how we’ve gotten ahead. We don’t know Izzie, we haven’t watched [Izzie and Alex] grow for five years, we weren’t there for their wedding, all we know is she’s a snappy broad who just got fired for making a stupid mistake. Will some compassion grow from there? Sure. But Reed is on her own there, I’m not the one chasing a married person. I will defend her only to a point.

TVGuide.com: What’s the dynamic like once Izzie returns to the hospital in the Nov. 12 episode?
Williams: I think everybody has a lot of unanswered questions for her. What the hell are you doing? What is your deal? Don’t take us all down for this and disappear. These are people that care about her, but on the outside, everybody is just concerned with what’s going to happen with her now. Alex is the one that takes it hard when she steps foot back in Seattle Grace.